Articles from ILiAD Biotechnologies, LLC

ILiAD Biotechnologies, LLC (ILiAD), an advanced clinical stage biotech company focused on the prevention and treatment of disease caused by Bordetella Pertussis, today announced the peer-reviewed publication of Phase 2b trial results in The Lancet Microbe (Link). The published research article summarizes the CHAMPION-1 clinical study of BPZE1, a randomized, double-blind, placebo-controlled study conducted in healthy adults in a controlled human infection model. BPZE1 is the leading next generation pertussis vaccine designed to induce comprehensive immunity for the prevention of B. pertussis infection, disease and transmission.

ILiAD Biotechnologies, LLC, a biotech company developing BPZE1, the most advanced next generation intranasal pertussis vaccine to protect against whooping cough, today announced that following a December 2024 Type C meeting with the United States Food and Drug Administration (FDA), ILiAD and hVIVO plc (hVIVO) have signed a Letter of Intent (LOI) to conduct a pivotal Phase 3 BPZE1 human challenge trial. hVIVO is a specialist contract research organization (CRO) and a world leader in human challenge models. A human challenge trial overcomes the complexities associated with conducting traditional Phase 3 field studies, which is particularly relevant for pertussis due to the unpredictability of B. pertussis outbreaks, which are currently widespread in the US and globally.

ILiAD Biotechnologies, LLC (ILiAD), a clinical stage biotech company developing the world’s most advanced next generation pertussis vaccine, today announced that COO Ken Solovay has died.

ILiAD Biotechnologies, LLC (ILiAD), a biotech company developing the most advanced next generation pertussis vaccine (BPZE1), today announced the company will be participating in the following investor conferences:

ILiAD Biotechnologies, LLC (ILiAD), a biotech company developing the most advanced next generation pertussis vaccine (BPZE1), announced today that Fierce Biotech has named the Company to the Fierce 15 2024 list (link), identifying ILiAD as one of the most promising and innovative biotechnology companies in the industry.

ILiAD Biotechnologies, LLC, a late-stage biotech development company dedicated to the prevention of disease caused by Bordetella pertussis, today announced the selection of Emmes Group, a global contract research and technology organization, to conduct upcoming Phase III studies of its lead pertussis vaccine candidate, BPZE1. ILiAD and Emmes Group are currently working to finalize the definitive agreement.

ILiAD Biotechnologies, LLC (ILiAD) reported today that BPZE1, the most advanced next generation pertussis vaccine, demonstrated positive topline interim results in the SUPER (Stand Up to Pertussis) school-age trial conducted in 366 participants in the United Kingdom, Australia and Costa Rica. The SUPER trial is the first multi-center, placebo-controlled, randomized study of BPZE1 in healthy children 6 - 17 years of age to assess the immunological response and safety of a single intranasal dose of BPZE1 with and without co-administration of tetanus, diphtheria, and acellular pertussis (Tdap, Boostrix®).

ILiAD Biotechnologies, LLC (ILiAD), a vaccine company utilizing its B-Tech technology to develop novel vaccines against infectious diseases, today announced Chief Medical Officer Stephanie Noviello, MD, MPH, will present data on its pertussis vaccine, BPZE1, at the World Vaccine Congress Europe in Barcelona, Spain (October 17 – 19, 2023).

ILiAD Biotechnologies, LLC (ILiAD), a clinical stage biotech company developing the world’s most advanced next generation pertussis vaccine announces positive primary data outcomes in the CHAMPION-1 clinical trial conducted at University Hospital Southampton (UK) and University of Oxford (UK).

ILiAD Biotechnologies, LLC (ILiAD), a vaccine company utilizing its B-Tech™ technology to develop novel vaccines against infectious diseases, today announced that Chief Medical Officer Stephanie Noviello, MD, MPH, will present information regarding its pertussis vaccine, BPZE1, at the World Vaccine Congress in Washington, DC (April 3 – 6, 2023).

ILiAD Biotechnologies, LLC (ILiAD), a vaccine company utilizing its B-Tech technology to develop novel vaccines against infectious diseases, today announced a peer-reviewed publication in The Lancet. The published research article summarizes the adult Phase 2b clinical study of BPZE1, the most advanced next generation pertussis vaccine.

ILiAD Biotechnologies, LLC (ILiAD), a clinical stage biotech company developing the world’s most advanced next generation pertussis vaccine, today announced the closing of a $42.8 million Class D round of financing. These funds will enable the company to conduct a Phase 2b Human Challenge study to determine if vaccination with BPZE1 prevents colonization from wild-type Bordetella pertussis infection.

ILiAD Biotechnologies, LLC (ILiAD), a vaccine company utilizing its B-Tech technology to develop novel vaccines against infectious diseases, today announced that multiple presentations and poster sessions reviewing data from Phase 2a and Phase 2b clinical trials of its lead pertussis vaccine candidate, BPZE1, are scheduled for the 13th International Bordetella Symposium to be held on June 26 – June 30, 2022 at the University of British Columbia.

ILiAD Biotechnologies today announced that the National Institute of Allergy and Infectious Diseases (NIAID) at the National Institutes of Health (NIH) has selected ILiAD’s B-Tech Vector Technology for funding as part of its newly created Innovation for Tuberculosis Vaccine Discovery (ITVD) program. This program supports novel innovative vaccine candidates for the prevention of tuberculosis.

ILiAD Biotechnologies, a late stage biotech development company focused on global eradication of disease due to Bordetella pertussis, today announced that the U.S. Food and Drug Administration (FDA) has granted Fast Track designation to BPZE1, a next generation vaccine for active booster immunization against pertussis.

ILiAD Biotechnologies announces enrollment of the first participants in the SUPER Trial (Standing Up to PERtussis) – the first study in school-age children of BPZE1, a live attenuated intranasal pertussis vaccine. The SUPER Trial is a multicenter, randomized, placebo-controlled, and observer-blinded Phase 2b study in healthy school age children across 12 to 16 sites in the United Kingdom and Australia to assess the immunological response and safety profile of a single dose of BPZE1 with and without co-administration of BOOSTRIX®. Approximately 600 participants 6 to 16 years old will be randomly assigned to one of three study groups.

ILiAD Biotechnologies, LLC (ILiAD) presented a breakthrough finding today on the effect of BPZE1, a live attenuated intranasal pertussis vaccine, on serum bactericidal activity (SBA) against PRN(+) and PRN(-) Bordetella pertussis strains at the virtual ID Week 2021 conference (sponsored by Infectious Disease Society of America). Pertactin (PRN) is a highly immunogenic virulence factor secreted by Bordetella pertussis (B. pertussis). Evolutionary changes in B. pertussis in response to selection pressure from acellular pertussis (aP) vaccines are believed to have led to variant strains that are PRN deficient (PRN-).